Epilepsy - Isnvenice

Category: Epilepsy

Published: 24 June 1999

JUNE 24 - 26, 1999

Session I
Epilepsy genes

Invited Speakers:
David Hosford - Duke University, Durham, CL
Epileptogenic mechanisms in genetic models of epilepsy
Timothy Pedley - Columbia University, New Yolk, NY
Genetic and epilepsy: the promise of the molecular revolution
Massimo Pandolfo - Mc Gill University Montreal, Canada
Linkage analysis in human generalized idiopathic epilepsies
Mathew During - Yale University New Haven, CT
Gene therapy: new perspectives
Jeffrey Nobels - Baylor College of Medicine Huston, TX
Inherited ion channel disorders and epilepsy
Dan Lowenstein - UCSF, San Francisco, CA
The role of the genes that control neuronal differentiation in the network changes associated with
temporal lobe epilepsy
Giuliano Avanzini - Istituto Neurologico, Milan, Italy
Ndn-inactivating sodium current in mutant mouse jolting
Bruce Tempel - University of Washington, Seattle, WA
Potassium channels genes and epilepsy
Antonio Simeone - IGB, Naples, Italy
OTX gene knockout mice with epilepsy
Rolf Sprengel - ZMVH Heidelberg, Germany
Molecular biology of ionotropic glutamate receptor channels
Invited Discussants
Federico Zara, Università di Genova, Italy


Session 2
Seizures and epileptogenesis: the role of GABA, neuropeptides and neurotrophins

Invited Speakers:
Salomon Moshe - Albert Einstein College Of Medicine, New York, NY
GABAa mediated modification of seizures in ensemble systems is age- and gender-dependent
Istvan Mody - UCLA, Reed Neurology Research Center Los Angeles, CA
Synaptic GABA receptors in temporal lobe epilepsy
Gunther Sperk - University of Innsbruck, Innsbruck, Austria.
Changes in the expression of GABAa and GABAb receptor subunits in experimental models of
seizures
Robert Sloviter - University of Arizona, Tucson, AZ Neuropeptides in synaptic plasticity and epileptogenesis.
William Colmers - University of Alberta, Edmonton, Canada
Presynaptic inhibition and neuropeptide Y in epilepsy
Annamaria Vezzani - Istituto Mario Negri for Pharmacological Research, Milan Italy
In vivo pharmacology of somatostatin and neuropeptide Y receptors in experimental models of seizures
Olle Lindvall - University of Lund Lund, Sweden
Expression studies of neurotrophins and their receptor in experimental models of seizures
Helen Scharfman - Helen Hayes Hospital, West Haverstraw, NY
Electrophysiological properties of brain derived neurotrophic factors and related neurotrophins in the limbic system
Susan Croll -Regeneron Pharmaceutical Tarrytown, NY
Biological and pharmacological tools for studying the functional role of neurotrophins in CNS
Invited Discussants
Carolyn Houser - UCLA, Los Angeles
Dan Mc Intyre - Carleton University, Ottawa, Canada

Session 3
Interactions between cellular, extracellular and vascular compartments in the

generation of epileptiform activity
invited Speakers:
Philip Schwartzkroin - Dept. Neurosurgery, University of Washington, Seattle.
Synchronization, excitability and control of neuronal activity
Oscar Herreras - Ramon y Cajal Hospital, Madrid, Spain
Andrea Volterra - Dept. Pharmacy, University of Milan
Reciprocal glia-neurons interactions in glutamatergic transmission
Mitchell Chesler - Dept. Neuroscience, New York University
Modifications of pH during neuronal activity
Damir Janigro - Dept. Neurological Surgery, University of Washington, Seattle.
The role of blood-brain barrier in brain excitability
Costantino ladecola - Dept. Cerebrovascular Biology and Stroke, University of Minnesota
Interaction between synaptic activity and cerebral microvessels: toward a cellular understanding
John Jefferys - Dept. Physiology, University of Birmingham
Network properties in cortical structures
Peter Carlen - Neuroscience Unit, University of Toronto
Gap junctions and field interactions in the generation of epi}eptiform activity
Uwe Heinemann - Dept. Neurophysiology, Humboldt University of Berlin
Field effect interactions, ion concentration and shrinkage of the extracellular space during seizures
Marco de Curtis - Dept. Neurophysiology, Istituto Neurologico, Milan Correlation between neuronal ictal discharges, extracellular pH and vascular tone changes in a model of focal epileptogenesis
Michael Haglund Div. Neurosurgery, Duke University, Durham.
Optical imaging of seizure onset and propagation in neocortex
Invited Discussants
Robert Wong
Robert Schwarcz - Maryland Psychiatric Research Ctr., University of Maryland
Ennio Ongini - Schearing-Plough, Milan, Italy
Yoel Yaari, University of Berlin, Berlin, Germany
Fernando Lopes da Silva University of Amsterdam, the Nederlands
Joan Abbot,
Roger Traub, Univ. of Birmingham, England
Session 3
Interactions between cellular extracellular and vascular compartments in the generation of epileptiform activity

Provisory program
8.30 Marco de Curtis - Wellcome address
8.40 Oscar Herreras (Chairman) - title of introduction to be defined
9.10 Andrea Volferra - Reciprocal glia-neurons interactions in glutamatergic transmission
9.50 Mitchell Chesler - Modifications of pH during neuronal activity
10.30 Damir Janigro - The interactions between glia and blood brain barrier in brain excitability
10.30 -10.50 Coffee break
10.50 Costantino ladecola - Interaction between synaptic activity and cerebral microvessels: toward a cellular understanding
11.30 John Jefferys - Network properties of cortical neurons and epileptogenesis
12.10 General discussion chaired by Oscar Herreras
12.50 -14.00 Lunch break
14.00 Philip Schwartzkroin (Chairman) Neuronal intentions with non-neuronal Factors in
epileptogenesis
15.10 Peter Carlen - Gap junctions and field interactions in the generation of epileptiform
activity
15.50 {ewe Heinemann - Field effect interactions, ion concentration and shrinkage of the
extracellular space during seizures
I5.50-16.10 Coffee break
16.10 Marco de Curtis - Correlation between ictal discharges, extracellular pH and vascular tone
changes in cortical epileptogenesis
16.50 Michael Haglund - Optical imaging of seizure onset and propagation in neocortex
17.30 General discussion chaired by Philiph Schwartzkroin
18.00 End of the session

Invited Speakers
Giuliano Avanzini - Istituto Neurologico, Milan, Italy
Peter Carlen - Neuroscience Unit, University of Toronto, Canada
Mitchell Chesler - Dept. Neuroscience, New York University, New York, USA
William Colmers - University of Alberta, Edmonton, Canada
Susan Croll -Regeneron Pharmaceutical, Tarrytown, NY, USA
Marco de Curtis - Dept. Neurophysiology, Istituto Neurologico, Milan, Italy
Mathew During- Yale University, New Haven, CT, USA
Michael Haggl Div. Neurosurgery, Duke University, Durham, USA
Uwe Heinemann - Dept. Neurophysiology, Humboldt University of Berlin
Oscar Herreras - Ramon y Cajal Hospital, Madrid' Spain
David Hosford - Duke University, Durham, CL, USA
Costantino Iadecola - D ept. . Cerebrovascular Biology and Stroke, University of Minnesota, USA
Damir Janigro - - Dept. Neurological Surgery, University of Washington, Seattle, WA, USA
John Jefferys - . Physiology, University of Birmingham, England
Olle Lindvall - University of Lund, Lund, Sweden
Dan Lowenstein - UCSF, San Francisco, CA, USA
lstvan Mody - UCLA, Reed Neurology Research Center, Los Angeles, CA, USA
Salomon Moshe - Albert Einstein College of Medicine, New York, NY, USA
Jeffrey Nobels - Baylor College of Medicine Huston, TX USA
Timothy Pedley - Columbia University, New York, NY, USA
Massimo Pandolfo - Mc Gill University Montreal, Canada
Helen Scharfman - Helen Hayes Hospital, West Haverstraw, NY, USA
Philip Schwartzkroin - Dept. Neurosurgery, University of Washington, Seattle, WA, USA
Antonio Simeone - IGB, Naples, Italy
Robert Sloviter - University of Arizona, Tucson, AZ, USA
Gunther Sperk - University of Innsbruck, Innsbruck:, Austria.
Rolf Sprengel - ZMVH, Heidelberg, Germany
Bruce Tempel - University of Washington, Seattle, WA, USA
Annamaria Vezzani - Istituto Mario Negri for Pharmacological Research, Milan, Italy
Andrea Volterra - Dept. Pharmacy, University of Milan, Italy
Invited Discussants
Robert Schwarcz - Maryland Psychiatric Research Ctr., University of Maryland, USA
Carolyn Houser - UCLA, Los Angeles, CA, USA
Dan Mc Intyre - Carleton University, Ottawa, Canada
Ennio Ongini - Schearing-Plough, Milan, Italy
Federico Sara, University di Genova, Italy
Robert Schwarcz - Maryland Psychiatric Research Ctr., University of Maryland Andreas Draguhn - Berlin Ennio Ongini - Schearing-Plough, Milan, Italy Roger Traub